Drug research proccess
The way we actually discover and develop new drugs is expensive, slow and it fails more often than it succeeds.
Cell tools in the last century
The available tools to test whether a drug is going to work before human clinical trials are failling: they do not predict what is going to happen in humans but they haven´t changed much in the last 100 years.
Cells in dishes
Cells in dishes are not in a dynamic environment, nor are they in the same architecture as in the human body (lack of mechanical and chemical stimulations
Animal models are more complex biological systems than cells in dishes, but animal testing is expensive, slow and controversial, due to ethical issues; also discrepancies are observed due to substantial differences between biological systems.
Organ on a Chip cell culture
Recent innovations in microfluidic technologies have produced organ-on-a-chip (OoC) platforms. They integrate advanced 3D tissue structures with microfluidic networks to minimize the shortcomings of in vitro 2D models.
Reproducing organs in your lab
OoC devices enable important physiological stimuli: vasculature and interstitial fluid flow, which improves the emulation of the in vivo physiological conditions for studying stem cell differentiation, methastasis… OoC used with human cells eliminates inter-species differences.