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Jan 26, 2018

Organ-on-Chip Development: Orchid Project

The website of Orchid has been inaugurated this month. We are glad to help in the communication of this project that plans to disseminate the Organ-on-Chip (OoC) technology to scientists, industry and society in general. We would like to congratulate the University of Zaragoza for being part of this initiative that will show to the world the importance of OoC technologies to reduce animal experimentation and reproduce as best as possible the human body on the laboratory.
Apart from the dissemination, this group of experts has other important objectives:

  • Identify ethical and regulatory issues
  • Analyse the impact of this technology on the economy, education, society…
  • Establish a road map for the Organ on Chip technology

This project shows us that the University of Zaragoza is one of the main European actors in this emerging and promising technology. For our advisory board, that works in the AMB group is a pleasure to share all their knowledge with great institutions from Belgium, France, Germany and Holland. The Dutch are leading this project and also the rise of this technology. Their government has planned to forbid animal experimentation in 2025 so they totally believe in the necessity of this transition to Organ-on-chip in the next years. For that reason, they have created an organization with all the companies interested in OoC called hDMT (Human organ and disease model technologies), a reference in the sector.

Volatile organic compound detection in vitro as biomarkers of tumor progression

Summary This paper describes the use of our Be-Gradient Barrier-Free device to simulate the ischemic conditions present in solid tumors, enabling the study of volatile organic compounds (VOCs) as biomarkers for tumor progression . This approach marks a notable...

Microfluidic chip design customization guide for optimal cell culture

Summary This guide summarizes Beonchip’s microfluidic chip design customization options to improve your cell culture model. It highlights the importance of channel dimensions in microfluidic chips for key aspects such as cell culture area, microscopy inspection, and...

Gravity-driven flow importance in Organ-on-chip applications

Summary Gravity-driven flow is paramount during the first stages of culture in organ-on-chip platforms. This study demonstrates oxygen consumption in a cellular monolayer within a microfluidic device and highlights the significance of gravitational-flow in maintaining...

Bioprinting in organ-on-chip applications

Summary Over the past few years, bioprinting has emerged as a compelling field of study. The field of organ-on-chip has particularly benefited from bioprinting applications, offering novel pathways to enhance in vitro cell culture methods. This technical note explores...

A microphysiological system for handling graphene-related materials under flow conditions

Summary Researchers from the University of Castilla la Mancha and University of Zaragoza have optimized a kidney-on-chip for graphene particle testing. The microfluidic system was placed under flow conditions to reduce the adsorption of graphene materials on the...

Improving cell-cell and cell-matrix contact area with custom designs of the Be-Transflow device

Summary At Beonchip, we provide standard cell culture platforms and the option to customize the channel dimensions or membrane pore size. Additionally, we offer services to adapt the device design for specific research needs. In this note, we’ll summarize the results...

Be-Gradient as a blood-brain barrier model

Summary Here we provide a comprehensive and brief overview of a scientific publication detailing the developmental journey of the Be-Gradient Barrier-Free device. In it, we elucidate its intricate design process and rigorous testing procedures in a collaborative...

Cell fixation, staining and immunostaining in a chip.

Introduction Protocols such as immunostaining on a chip are frequently searched for, at the moment. Cell fixation and immunostaining are critical techniques in cell biology and biomedical research. Cell fixation is the process of immobilising cells in a particular...

Be-Transflow device as an epithelium-on-a-chip model for permeability studies

Researchers from the University of Zaragoza have employed a Beonchip microfluidic device to develop a stratified epithelia-on-a-chip model, showcasing the Be-Transflow as an epithelium-on-chip model for permeability studies.Figure 1 Be-Transflow device. Introduction...

Organoids-on-chip

In this note, we summarise the possible combination of two technologies, organoids and microfluidic devices, in what is also known as organoids-on-chip. What is an organoid and why use it in research? There has been an increasing shift towards the development of 3D...
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