Last week we had the visit of our Dutch colleagues of ACTA and Ocello, partners in one of the Euopean projects that we are involved about Bone on a Chip. During two days we explained our developments of the last 6 months and discuss about possible improvements in the different areas involved in the design and validation of the new device.

BONAFIDE will develop, validate and deliver an in vitro human bone-on-chip platform that will simulate bone growth, resorption and remodeling for medium/ high throughput evaluation of drugs (e.g. anti-osteoporosis, nutrients, and biomaterials (e.g. bone cements). The BONAFIDE platform can be directly implemented in the preclinical workflow of companies and consists of a microfluidic chip containing a bone-mimetic matrix and standard operating procedures for human bone culture.

To build organs on a chip, it is neccesary to combine multiple types of cells from an organ on a microfluidic chip, while steadily supplying nutrients, removing waste, and applying mechanical forces the tissues would face in the body. In the future, the researchers could potentially grow human bones  in immune-deficient mice.

BE-Doubleflow App. notes: Gut-on-chip 2

Introduction In our previous technical note “BE-Doubleflow App. notes: Gut-on-chip 1” we explored our device BE-Doubleflow for gut-on-a-chip (GOC) models in collaboration with AINIA. In that note we compared our device with an insert platform with GOC outperforming...

Project: MITI2

MITI2: Gut Microbiota-Induced Tregs for Inflammatory-Bowel-Disease (IBD) Immunotherapy Last 5th of July, we took part in the kick-off meeting in Nantes of a R&D project lead by INSERM in which Beonchip will be participating in the next 4 years.MITI2 focuses on the...

Cell recovery protocol

Overview One of the strongest advantages of BEOnChip devices is their compatibility with microscopy which allows the monitoring of the cell culture overtime or at designated time points. However, there are several cell features that are important to evaluate, such as...

BE-Doubleflow App. notes: Gut-on-chip 1

Table of Contents Introduction.................................................................................................................. 1...

Project: MICROGUT

Reproduction of the microenvironment of the gastrointestinal tract for the nutritional study of alternative proteins and their interaction with the microbiota The MICROGUT project aims to investigate the nutritional quality and microbiota interaction of novel protein...