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Apr 13, 2020

Goodbye Flat Biology – Welcome Organ on a Chip

This editorial of Nature could perfectly be the kick off of the Organ on a Chip technology. This new market is still in definition and we don’t even have clear the precise definition of Organ on a Chip. In Europe, the consortium Orchid is planning to write a “white book” about it during next years, so possibly we will be able to have soon all rules about this new trend.

Petri dishes have been used for more than a century for cell culture and we had to wait till the beginning of the XXI century to hear some voices asking for a change in cell culture. In flat dishes cells are cultured in 2D, very far from the behavior in the human body. 3 dimensions were needed to reproduce most of the activities that occurred in vivo, and we have even found that some cells behave totally different in 2D and 3D, becoming false positives in the laboratory compared to the clinical trials done in humans or animals.

In 2003 the possibility to work in 3D seemed too far for costs and technology reasons, but nowadays it´s quite cheap to work in 3 dimensions even adding flow that solves other of the main problems of the Petri dish (lack of stimuli). A revolution like this needs some time to convince researchers, but in this particular case, benefits are so clear for them that it´s just a matter of time a global transition in the cell culture sector to a technology that will make experimentation much more efficient than before.

One of the most popular congresses of the sector is now called Goodbye Flat Biology, possibly as a tribute to this prediction of Nature, being the beginning of the Organ on a Chip revolution that has already arrived and it´s going to change the way we know cell culture till now.

BE-Gradient as a blood-brain barrier model

Summary Here we provide a comprehensive and brief overview of a scientific publication detailing the developmental journey of the BE-Gradient Barrier-Free device. In it we elucidate its intricate design process and rigorous testing procedures in a collaborative effort...

Cell fixation, staining and immunostaining in a chip.

Introduction Cell fixation and immunostaining are critical techniques in cell biology and biomedical research. Cell fixation is the process of immobilising cells in a particular state, preserving their morphology, and preventing any further changes. This is crucial...

BE-Transflow device as an epithelium-on-a-chip model for permeability studies

Researchers from the University of Zaragoza have employed the Be-Transflow device to develop a stratified epithelia-on-a-chip model, highlighting this device as a useful platform for permeability studies.Figure 1 BE-Transflow device. Replicating the permeability of a...

Organoids on chip

What is an organoid and why use it in research? There has been an increasing shift towards the development of 3D cell culture models in attempts to create an increased complexity that can be compared with the in vivo better than 2D models. From the different 3D...

How to perform Cellular Extraction in a Beonchip device: Step-bt-step guide

This graphical abstract was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unparted licence”. Overview One of the strongest advantages of BEOnChip devices is their compatibility with microscopy which...

BE-Gradient Barrier-Free applications: Hydrogel confinement and diffusion profile

Introduction Our new design BE-Gradient Barrier-Free is a device designed for 3D culture where a central chamber is linked with two fluidic lateral channels (Figure 1). The innovation we present is the absence of any physical barrier between the central chamber and...

BE-Doubleflow App. notes: Gut-on-chip 2

Introduction In our previous technical note “BE-Doubleflow App. notes: Gut-on-chip 1” we explored our device BE-Doubleflow for gut-on-a-chip (GOC) models in collaboration with AINIA. In that note we compared our device with an insert platform with GOC outperforming...

Project: MITI2

MITI2: Gut Microbiota-Induced Tregs for Inflammatory-Bowel-Disease (IBD) Immunotherapy Last 5th of July, we took part in the kick-off meeting in Nantes of a R&D project lead by INSERM in which Beonchip will be participating in the next 4 years.MITI2 focuses on the...

BE-Doubleflow App. notes: Gut-on-chip 1

Table of Contents Introduction.................................................................................................................. 1...

Project: MICROGUT

Reproduction of the microenvironment of the gastrointestinal tract for the nutritional study of alternative proteins and their interaction with the microbiota The MICROGUT project aims to investigate the nutritional quality and microbiota interaction of novel protein...
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