Organ on a Chip models try to reproduce some applications of a human organ in a lab. One of the most interesting activities for the food industry would be the simulation of the absortion of the intestine (Gut on a Chip). The development of this approach would change the way to treat patients with some diseases such as Crohn´s disease or syndrome of the irritable intestine.

Instead of using pharmacological treatments that can be inefficient and with secondary effects, scientists could use own mother cells of the patient to generate a duplicate of the intestine coating on a chip, having the possibility to analyze different drugs on it. This Gut on a Chip would allow biomedical scientists to study the performance of a intestinal coating on a controlled environment, where this coating can interact with immunitary cells, blood cells and drugs and without any invasive surgery.

Gut on a Chip tries to be a “home in a lab” for human cells and gives them the appropriate environment and biological stimuli that they need to behave as they do in the human body. This recreation includes the intestinal epithelium, a layer of cells that forms the coating of the small and large intestine. Flow passes through the microchannels of these chips, recreating three-dimensional structures similar to the hairiness that can be found in the intestine.

Beonchip has already a prototype of this Gut on a Chip and we are in the validation process trying to use the different cell types that can be found on the intestine. This absortion simulation would open us the market of the food industry that need an efficient way to test the behavior of different compounds that can be found in food.

 

Organoids on chip

What is an organoid and why use it in research? There has been an increasing shift towards the development of 3D cell culture models in attempts to create an increased complexity that can be compared with the in vivo better than 2D models. From the different 3D...

BE-Transflow device as an epithelium-on-a-chip model for permeability studies

Researchers from the University of Zaragoza have employed the Be-Transflow device to develop a stratified epithelia-on-a-chip model, highlighting this device as a useful platform for permeability studies.     Replicating the permeability of a tissue barrier is pivotal...

BE-Gradient Barrier-Free applications: Hydrogel confinement and diffusion profile

Introduction Our new design BE-Gradient Barrier-Free is a device designed for 3D culture where a central chamber is linked with two fluidic lateral channels (Figure 1). The innovation we present is the absence of any physical barrier between the central chamber and...

BE-Doubleflow App. notes: Gut-on-chip 2

Introduction In our previous technical note “BE-Doubleflow App. notes: Gut-on-chip 1” we explored our device BE-Doubleflow for gut-on-a-chip (GOC) models in collaboration with AINIA. In that note we compared our device with an insert platform with GOC outperforming...

Project: MITI2

MITI2: Gut Microbiota-Induced Tregs for Inflammatory-Bowel-Disease (IBD) Immunotherapy Last 5th of July, we took part in the kick-off meeting in Nantes of a R&D project lead by INSERM in which Beonchip will be participating in the next 4 years.MITI2 focuses on the...