The well seal effectively isolates the culture from the external environment while providing fluidic resistance. It is designed to prevent medium overflow into the well when high pressure builds in the perfused lower channel. By maintaining a secure seal, it ensures consistent flow in the lower channel, preserving a sterile environment. Additionally, its optically clear and transparent properties make it well-suited for microscopy. The adhesive allows for easy removal during or after the experiment, enabling direct access to the sample for complete insert retrieval. These seals are available in packages of 20 units.