News & Blog

GrowDex®-T in a commercial organ-on-a-chip under active flow

GrowDex®-T in a commercial organ-on-a-chip under active flow

The aim of this study was to establish a 3D environment using GrowDex-T, an animalfree
nanofibrillar cellulose hydrogel, in a commercial organ-on-chip device that could
endure long-term active flow. We tested different GrowDex-T concentrations in BEDoubleflow
chips and connected them to the flow from a peristaltic
pump for 7 days. During these flow experiments, the overall performance and barrier
integrity of GrowDex-T was assessed.

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Intestinal epithelial monolayer formation using CACO-2 perfused with BE-FLOW and FLOW EZ™

Intestinal epithelial monolayer formation using CACO-2 perfused with BE-FLOW and FLOW EZ™

Gut-on-a-chip models offer a powerful in vitro platform for studying the physiology and patho-
physiology of the intestine. The gut is home to a microbiome that plays an important role in
health and disease. Some of these microorganisms survive the hypoxic conditions found in the
intestine. Most commensal microbes in the digestive system are anaerobic and require low
levels of oxygen1. The BE-FLOW microfluidic device is made of a Cyclic Olefin Polymer (COP).
This material is impermeable to gases and allows the control of gas concentration within the
devices. Overall, this system offers a way to control the microenvironment of the intestinal
epithelium that is closer to the physiological state.

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Organ on a chip 101

Organ on a chip 101

Organ on a chip for beginners. An introduction to the origins of Organ on chip technology and its groundbreaking potential to became the new paradigm in in vitro cell culture.

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Peristaltic pump vs pressure-based microfluidic flow control sytems for Organ on chip applications

Peristaltic pump vs pressure-based microfluidic flow control sytems for Organ on chip applications

The development of microfluidic research applied to cell culture has revealed the need to generate more accurate propulsion systems with high stability and pulseless flow. In this way, pressure pumps emerge instead of peristaltic pumps that have been widely used but create alterations in the flow rate.
This application note illustrates the effect of flow generated by a peristaltic or a pressure pump applied to a microfluidic system’s cell culture.

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Goodbye Flat Biology – Welcome Organ on a Chip

Goodbye Flat Biology – Welcome Organ on a Chip

This editorial of Nature could perfectly be the kick off of the Organ on a Chip technology. This new market is still in definition and we don’t even have clear the precise definition of Organ on a Chip. In Europe, the consortium Orchid is planning to write a “white book” about it during next years, so possibly we will be able to have soon all rules about this new trend.

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Boston calling!

Boston calling!

Next month we are travelling three weeks to Boston thanks to the Richi Entrepeneurs. This program helps companies around the world to land in USA through Massachussets, one of the most interesting areas of the country, especially for biotech companies. Richi Entrepeneurs assigns each participant a mentor with the idea to help them looking for potential clients, investors, clusters… and also they try to do some seminars to explain the main differences between Europe and America in different topics: business culture, patents, certifications needed.

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Simulating a gut on a chip

Simulating a gut on a chip

Organ on a Chip models try to reproduce some applications of a human organ in a lab. One of the most interesting activities for the food industry would be the simulation of the absortion of the intestine (Gut on a Chip). The development of this approach would change the way to treat patients with some diseases such as Crohn´s disease or syndrome of the irritable intestine.

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