News & Blog
Organ on a chip for beginners. An introduction to the origins of Organ on chip technology and its groundbreaking potential to became the new paradigm in in vitro cell culture.
Cancer continues to be one of the leading causes of death worldwide and about one out every six deaths is caused by this disease. However, recreating realistic model of a micro-tumour remains a challenge for the scientific community.
Here, we explore the opportunities that microfluidics offers to overcome this problem.
The development of microfluidic research applied to cell culture has revealed the need to generate more accurate propulsion systems with high stability and pulseless flow. In this way, pressure pumps emerge instead of peristaltic pumps that have been widely used but create alterations in the flow rate.
This application note illustrates the effect of flow generated by a peristaltic or a pressure pump applied to a microfluidic system’s cell culture.
This editorial of Nature could perfectly be the kick off of the Organ on a Chip technology. This new market is still in definition and we don’t even have clear the precise definition of Organ on a Chip. In Europe, the consortium Orchid is planning to write a “white book” about it during next years, so possibly we will be able to have soon all rules about this new trend.
Next month we are travelling three weeks to Boston thanks to the Richi Entrepeneurs. This program helps companies around the world to land in USA through Massachussets, one of the most interesting areas of the country, especially for biotech companies. Richi Entrepeneurs assigns each participant a mentor with the idea to help them looking for potential clients, investors, clusters… and also they try to do some seminars to explain the main differences between Europe and America in different topics: business culture, patents, certifications needed.
Organ on a Chip models try to reproduce some applications of a human organ in a lab. One of the most interesting activities for the food industry would be the simulation of the absortion of the intestine (Gut on a Chip). The development of this approach would change the way to treat patients with some diseases such as Crohn´s disease or syndrome of the irritable intestine.
Last week we had the visit of our Dutch colleagues of ACTA and Ocello, partners in one of the Euopean projects that we are involved about Bone on a Chip. During two days we explained our developments of the last 6 months and discuss about possible improvements in the different areas involved in the design and validation of the new device.
The website of Orchid has been inaugurated this month. We are glad to help in the communication of this project that plans to disseminate the Organ on Chip technology to scientists, industry and society in general. We would like to congratulate the University of Zaragoza for being part of this initiative that will show to the world the importance of OoC technologies to reduce animal experimentation and reproduce as best as possible the human body on the laboratory.
Last Friday 26th we did a small workshop of our products to EYOWN Technologies, a biotech company from Madrid, specialized in the optimization of laboratory processes through instrumentation and Biocomputing tools.
This week we are travelling to Paris to attend the kick off of a challenging European project called “Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine”.
The main goal of this project is to create a heart on a chip model by using microfluidics and developing a platform for cardiomyocytes-iPSCs. These human-induced pluripotent stem cells are very useful in OoC devices because they are derived in a patient-matched manner making them a great element for personalized medicine.